Woman experiencing headache lying in bed in darkened room.

Small Doses of Psychedelics for Cluster Headaches

By Bob Wold

One understudied condition for which small doses of psychedelic substances such as psilocybin may be beneficial is cluster headache.

As founder and executive director of the advocacy group Clusterbusters, I have seen firsthand, as a patient and an activist, that, despite its modest name, cluster is far from “just” a headache. It is a chronic pain condition that lasts “on” and “off” for months or years, often with no hint as to its origin. Estimates suggest that one in 1,000 people – which equates to over 332,000 Americans – suffer from cluster headache.

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