The False Promise of Smart Pills in a Loosely Regulated Market

by Spencer Andrews

We’ve all had the experience: you receive a targeted ad on your phone or computer which mysteriously seems to read your mind. This happened to me recently when I, a busy law student, began receiving a wave of ads selling supplements which purport to improve brain focus, clarity, and memory. I had been thinking about ways to increase my productivity, and just in the nick of time, a miracle drug appeared to answer my need. As it turns out, the product being advertised was of a little-known class of substances known as nootropics. And as you might expect, nootropics are hardly a miracle drug.

What is a Nootropic?

The word nootropic is colloquially used to describe a wide range of natural and synthetic substances thought to have cognitive enhancing properties. Romanian psychologist and chemist Corneliu Giurgea coined the term nootropic in the 1970s. He first used the term after synthesizing piracetam, a compound which he claimed would improve cognitive functions like memory and learning. Clinical studies have since shown that piracetam is not a dependable cognitive enhancer nor does it have long-term efficacy against cognitive impairment. Nonetheless, it has shown modest efficacy as an anti-depressant, and most recently, it has demonstrated some promise as a neuroprotective drug for patients undergoing coronary bypass surgery. Notwithstanding piracetam’s clinical success, or lack thereof, the term nootropic has since evolved into something else entirely.

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The Uncertain Future of Probiotics

By Patrick O’Leary

In the October 22 edition of The New Yorker, Michael Specter wrote a fascinating article about the growing and exciting science of the human microbiome, the ecosystem of ten thousand or so bacterial species that call each of our bodies home. The hype around this particular field of scientific and medical inquiry is intense: Specter quotes David Relman of Stanford Medical school as saying that right now we are in the “beautiful, euphoric, heady early period” of the field, and notes that each week seems to bring additional symposia, publications, and grants for new research. All of this is for good reason. Promising studies have indicated that microbial therapy (the intentional introduction of certain bacteria into the body) can be an effective treatment for some diseases, while other researchers have suggested that a variety of modern diseases (like asthma, inflammatory-bowel disease, and some allergies) may be tied to changes in the human bacterial ecosystem. In some ways, this isn’t news: as Dr. Douglas Archer noted in an FDA advisory committee meeting on probiotics over a decade ago, using food with live cultures to treat disease is a longstanding practice dating at least as far back as 76 BC, when the Roman historian Plinio advocated using fermented milk to treat GI infections.  Read More